[Research Frontier] New Trends in Prime Editing: Point Mutated Cells for Preclinical Gene Therapy
Prime editing is an improved gene editing technology based on the CRISPR/Cas system to achieve precise fragment insertion, deletion, and arbitrary substitution of bases at the target site of the genome, with higher accuracy and lower error rate. When it came out, it attracted widespread attention from many scientific researchers, and extensive research was conducted on the treatment of hereditary diseases, gene mutation diseases, and cancers. For example, correcting the mutant genes to treat genetic diseases or editing oncogenes in cancer cell genomes to prevent them from growing and spreading. The following three articles are about the clinical treatment of Prime Editing, bringing you the latest research trends. Prime editing helps in the treatment of β - thalassemia, and no off-target effect was detected β - thalassemia is a hematopoietic system disease caused by a single gene mutation in the hemoglobin (HGB) subunit beta gene (HBB), res...